Combining biological and electrical stimulation therapies following spinal cord injury

Stem Cells for Recovery of Human Central Nervous System Function. " In response to the Route 28 challenge, we propose a novel combinatorial treatment approach using multiple biological interventions in conjunction with controlled electrical stimulation to enhance the benefits of a cellular replacement strategy. Using an aligned polymer scaffold seeded with embryonic neural stem cells, we aim to create a relay for the disconnected axons in a transection rodent model of spinal cord injury. This approach will be implemented with (1) a growth factor gradient, (2) chondroitinase ABC (chABC) injections, and (3) functional electrical stimulation and in situ-recording. We hope to create an environment that is supportive for stem cell survival and differentiation to facilitate neural relays, long distance host axonal regeneration, and functional recovery.